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What is

Why mutations matter

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Once you or your loved one receives an AML diagnosis, doctors will perform lab tests to find out more about the disease and if you have a mutation, such as FLT3-ITD. A mutation in AML is a change in the genes that causes leukemia cells to grow rapidly and multiply differently.

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Knowing what mutations you have is important. Certain mutations have a more serious impact on your health compared to other mutations.

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Some cancer cells have certain gene mutations. FLT3 is one of the genes found in healthy blood cells that helps blood cells develop. It's important to talk to your doctor and ask about testing for mutations.

Quick Poll

Do you know the difference between FLT3-ITD and FLT3-TKD mutations?


Knowing which mutation you may have can help your doctor select the appropriate treatment for you. Doctors test for mutations with bone marrow or blood tests. This gives them more information about your type of AML.

In AML, there are many mutations, but one of the most common is the FLT3 mutation. FLT3 mutations include the ITD subtype, which can be present at diagnosis or appear later on.

The ITD mutation is the most common type of mutation in the FLT3 gene and is known to cause cancer to grow or spread quickly. Because of this, getting tested for FLT3 mutations, specifically the ITD mutation, is key to getting you on the appropriate treatment.

Portrayal of a doctor testing for the FLT3-ITD mutation
Testing for the FLT3-ITD
mutation may allow
doctors to find out if
VANFLYTA is right for you
Actor potrayal.
Testing for the FLT3-ITD mutation may allow doctors to find out if VANFLYTA is right for you

If the blood and bone marrow test found that you have the FLT3-ITD mutation, doctors may prescribe VANFLYTA, which was specifically developed to treat adult patients with newly diagnosed FLT3-ITD+ AML.

Treatment for FLT3-ITD+ AML

When you or a loved one is first diagnosed with FLT3-ITD+ AML, it can be overwhelming. Stay in regular contact with your doctor and ask any questions to help you better understand the next steps of treatment.

To help, we have created a discussion guide that lists a series of questions to support conversations with you or your loved one's prescribing physician. We hope this guide is helpful and gives you confidence during your VANFLYTA treatment journey.